![]() Both symptoms are common among patients who experience recurrent UTIs. In mice that had experienced multiple UTIs, this physical change reduced bladder capacity and increased voiding frequency. With each recurring UTI, the researchers reported, bladder tissue repair occurs more robustly and at a faster rate, resulting in a markedly thicker bladder cell lining. This focus on bladder wall repair hampers complete clearing of bacteria from the bladder, leaving behind pathogens that bloom into another infection. ![]() The pain caused by urine-induced tissue damage is a greater immediate threat than the bacteria that persist in the bladder, according to the researchers. “Because of the harm urine can cause to the unprotected bladder wall, it is not surprising the bladder prioritizes recovery of its plaque-covered inner wall lining over bacterial clearance during infection,” said graduate student Jianxuan Wu, lead author of the study. Loss of this barrier exposes the underlying bladder tissue, leading to severe bladder wall damage and pain. However, the sloughing process removes the thick plaque of cells that protects the bladder walls from salts and toxins in urine. Large numbers of bacteria bind to bladder cell surfaces, so shedding this wall tissue is a natural immune defense. ![]() Researchers learned that the bladder’s intitial response emphasizes shedding cells from internal walls to reduce bacterial load. However, in the bladder, the response prioritizes tissue repair - a tendency that increases with each successive infection. Throughout the body, immune responses to infections are generally balanced between bacterial clearance and tissue repair. To study the immune response, Abraham and colleagues infected mouse bladders with E.coli. “In a substantial proportion of these women, UTIs become recurrent with painful frequency.” “Most women will experience at least one UTI in their lifetime,” said senior author Soman Abraham, Ph.D., a professor in the departments of Pathology, Immunology and Molecular Genetics and Microbiology at Duke University School of Medicine. The researchers said the findings, publishing online May 18 in the journal Nature Immunology, improve the possibility of identifying more effective ways to treat urinary tract infections, or UTIs, which are especially common among women. These two related conditions are caused by an aberrant immune response that prioritizes repairing tissue in the bladder wall over clearing the bacteria, according to a new study led by Duke Health researchers.
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